Conditions the medication is used for: Schizophrenia, Psychoses, Obsessive-Compulsive Disorder, Dementia, Behavioural problems

Other names for the medication: Solian®

The medication may look like: Amisulpride comes in tablet form Solian comes in tablet form and are scored, both Amilsulpride and Solian come in doses of 50, 100, 200 & 400mg. Solian also comes in an oral solution and is caramel flavoured, 100mg/1ml

What is this medication used for?

This belongs to the group of medicines known as antipsychotics.

  • Amisulpride works by acting on several chemical transmitters in the brain. 
  • Amisulpride (also known as Solian®) is mainly used to help treat the symptoms of psychosis, schizophrenia and mania, and to help stop the symptoms coming back. It can also sometimes be used to help dementia, OCD and behavioural disorders.
  • Amisulpride is made as tablets and a syrup.

What is the usual dose for this medication?

The usual dose of amisulpride is around 100mg to 1000mg a day. It can be up to 1200mg a day and should be lower in older people.

How and when should I take the medication?

How to take:

Swallow the tablets with at least half a glass of water whilst sitting or standing. This is to make sure that they reach the stomach and do not stick in your throat. For the liquid, use a medicine spoon or oral syringe. Use it carefully to make sure you measure the correct amount.

When to take:

Take your Amisulpride as directed on the medicine label. Try to take it at regular times each day. Taking it at mealtimes may make it easier for you to remember as there is no problem about taking Amisulpride with or after food. If the label says to take it once a day this is usually best at bedtime as it may make you drowsy at first.

What are the alternatives to this medication?

There are many other antipsychotics, talking therapies and treatments for psychosis, schizophrenia, mania and other symptoms. See our “Handy chart” to help you compare the medicines, how they work and their side effects.

How long does the medication take to work?

This will depend on what you are taking it for. It varies but can start in a few days and the effect builds over the next few weeks. Please look at the “Handy charts” for more advice on how long you might need to take it for.

How long will I need to keep taking this medication for?

This will depend on how well your symptoms are controlled. Please look at the “Handy charts” for more help and advice on how long you might need to take it for. It can be months or years.

Can I just stop taking this medication?

It is unwise to stop taking it suddenly, even if you feel better. Your symptoms can return if treatment is stopped too early. This may occur some weeks or even many months after amisulpride has stopped. When the time comes, you should stop amisulpride by a gradual reduction in the dose taken over several weeks. You should discuss this fully with your doctor.

What should I do if I forget to take a dose or overdose?

Take the missed dose as soon as you remember unless it is within about 3-4 hours of your next dose. If you remember after this just take the next dose as normal. Do not try to catch up by taking two doses at once as you may get more side-effects. If you have problems remembering your doses (as very many people do) ask your pharmacist, doctor or nurse about this. There are some special packs that can be used to help you remember.

Can I drink alcohol while on this medication?

If you drink alcohol while taking amisulpride it may make you feel more sleepy. This is particularly important if you need to drive or operate machinery. You must seek advice on this.

Will this medication affect my other medications Including the Contraceptive pill?

Amisulpride has only a few interactions with other medicines.

  • The effect of amisulpride can be decreased by sucralfate or indigestion treatments with aluminium in them If amisulpride is taken with benzodiazepines (e.g. diazepam, lorazepam, temazepam), hypnotics or alcohol, it may cause more sleepiness
  • You should have no problems with "The Contraceptive Pill" and amisulpride

Not all of these interactions happen in everyone. Some of these medicines can still be used together but you will need to follow your doctor's instructions carefully. There are many other possible drug interactions.

What sort of side-effects might I get from taking this medication?

Side effect

What happens

What to do about it

VERY COMMON (more than about 1 in 10 people might get these)

Sleepiness

Feeling sleepy, drowsy or sluggish. It can last for a few hours after taking a dose.

Don't drive or use machinery. Ask your doctor if you can take your amisulpride at a different time.

Movement disorders (extra-pyramidal side effects)

Having shaky hands. Your eyes and tongue may move on their own. You may feel very restless, or stiff.

It is not usually dangerous but is a well known side effect. If it is distressing or worries you, tell your doctor. He or she may be able to give you a medicine for it e.g. an anticholinergic.

COMMON (fewer than about 1 in 10 people might get these)

Postural hypotension

Low blood pressure - this can make you feel dizzy when you stand up.

Try not to stand up too quickly. If you feel dizzy, don't drive.

Headache

When your head is painful.

Try paracetamol. Your pharmacist will be able to advise if this is safe to take with any other medicines you may be taking.

Akathisia

Feeling more on edge and restless. You may sweat a lot more.

Try and relax by taking deep breaths. Wear loose fitting clothes.

Raised prolactin (hyperprolactinaemia)

It can affect breasts (including milk being leaked) and irregular or no periods in women, or cause impotence and chest changes in men.

It can be very distressing. Discuss with your doctor when you next see him or her as it may possibly even affect your bones if prolactin is raised for a long time.

Constipation

When you want to poop but can't (the opposite of diarrhoea). You can't pass a motion.

Make sure you eat enough fibre, cereal or fruit. Make sure you are drinking enough fluid. Keep active and get some exercise e.g. walking. If this does not help, ask your doctor or pharmacist for a mild laxative.

UNCOMMON (fewer than about 1 in 100 people might get these)

Blurred vision

Things look fuzzy and you can't focus your eyes properly.

Don't drive. See your doctor if you are worried.

Weight gain

Eating more and putting on weight.

A diet full of vegetables and fibre may help prevent weight gain. Ask for advice.

Sexual dysfunction

Finding it hard to have an orgasm. No desire for sex.

Discuss with your doctor.

Skin rashes

Blotches on the skin.

Stop taking - see your doctor now.

 

Do not be worried by this list of side effects. Some people get no side effects at all and others may get some effects that are not listed in this table. If you think you might have a side effect to your medicine, you should ask your doctor, nurse or pharmacist.

Will I need to have blood tests?

If you have bipolar disorder, schizophrenia or other long-term mental health problem, it is important to look after your physical health as well. National guidelines recommend that you should at least have your blood pressure, weight, blood glucose and blood fats (e.g. lipids, cholesterol) checked regularly. This may be done by a hospital to start with, but after that your GP should arrange for all these to be checked at least every year. And then to do something about it if there is anything that needs treating.

Can I drive or cycle while on this medication?

You may feel a bit sleepy at first when taking amisulpride. Until this wears off, or you know how amisulpride affects you, do not drive or operate machinery. You should be careful as it may slow down your reaction times.