Neurological manifestations of primary immunodeficiencies (Chavoshzadeh, Hashemitari, Darougar, 2018)

Chavoshzadeh Z. Hashemitari A. Darougar S. 

Iranian Journal of Child Neurology 2018;12(3): 7. 

Available online at this link 

Objective: Primary immunodeficiencies (PID) are a heterogeneous group of disorders with a variable clinical spectrum of manifestations. The central nervous system may be involved in PID with symptoms which may present initially or develop at later stages. The purpose of this study was to review the neurological manifestations of different PID syndromes. Material(s) and Method(s): We focused on 104 selected studies on PID with certain neurological abnormalities which may accompany these disorders or may later signify a PID in their course. Result(s): Diverse neurological deficits accompanying certain PIDs may be mild or they may greatly influence the course of the disease with major impacts on the quality of life of these patients. Conclusion(s): Early recognition and treatment is important to prevent or reduce future irreversible neurological sequelae. Therefore physicians should be aware of the neurological features accompanying PID.Copyright © 2018, Iranian Child Neurology Society. All rights reserved.