Psychometric analysis of the adult sickle cell quality of life measurement information system (ACSQ-Me) in a UK population (Tangayi, Mulligan, 2019)

Cooper O. McBain H. Tangayi S. Telfer P. Tsitsikas D. Yardumian A. Mulligan K. 

Health and Quality of Life Outcomes 2019;17(1): 74. 

Available online at this link 

Background: The Adult Sickle Cell Quality of Life Measurement Information System (ASCQ-Me) has been shown to be a reliable and valid questionnaire measuring health-related quality of life (HRQoL) in the US sickle cell disease (SCD) population. The study objective was to test the validity and reliability of the ASCQ-Me for use in the UK. Method(s): The US ASCQ-Me, Hospital Anxiety and Depression Scale (HADS), self-reported symptoms, and Medical Outcome Survey Short Form 36 (SF-36) were administered to 173 patients with SCD. Clinical severity was assessed by the number of painful episodes indicated by hospital admissions. Result(s): The results showed that the item banks of the UK ASCQ-Me had good internal consistency. Anxiety and depression were strongly correlated with the emotional, and social item banks of the UK ASCQ-Me, with moderate correlations between the UK ASCQ-Me item banks and SF-36 components suggesting convergent validity. A confirmatory factor analysis confirmed the conceptual framework of the scale as being the same as the US ASCQ-Me, indicating construct validity. Known groups validity was found, with the ASCQ-Me being able to differentiate by SCD severity groups. Conclusion(s): The analysis of the sample shows evidence of both validity and reliability of the ASCQ-Me for use in the UK SCD population.Copyright © 2019 The Author(s).